In this collection of reviews (2. Sample and Clinical Data, 3. Brain Function, 4. Genetics and 5. Functional Genomics), the reader will find a deep characterization of the various data that comprise COGA, the motivation and procedures for collection, and snapshots of the scientific insights that COGA has contributed to the field of alcohol research. This reflection represents over three decades of research which began with the simple, important yet unanswered question: how does AUD emerge and manifest in families, and what are the factors that exacerbate or mitigate its progression? Relying on our multi‐modal data framework within a longitudinal context, we continue to identify new approaches and avenues to answer not only this question but the myriad of questions that arise as our knowledge of risk and resilience to AUD over the lifespan increases. Our data have also begun to produce exciting insights into possible prevention and intervention paradigms through independent studies (e.g., References 60, 61, 62, 63). There are numerous priority areas in the field of alcohol research where COGA continues to have scientific impact. For example, while
