Analyses were conducted using a multilevel regression-based framework (Singer, 1998) using PROC MIXED in SAS Version 9.1 to test genotype group differences on subjective responses to alcohol. The critical p-value was set at p< .05 for all analyses. All analyses were modeled with individual intercepts and linear slopes across rising BrAC levels. Specifically, in the multilevel models, Alcohol and Genotype were Level 1 variables (nested within subjects), while subject and BrAC were Level 2 variables. The primary analyses of genotype effects examined the effects of Alcohol, a two-level within subjects factor (Alcoholvs. Saline, coded 0 and 1), Genotype, a two-level between subjects factor (A-allele hyomozygotes vs. G-allele carriers, coded 0 and 1), Time, a four level within subjects factor (0 at baseline, 1 at BrAC = 0.02 g/dl or 18 min, 2 at BrAC = 0.04 g/dl or 43 min, and 3 at BrAC = 0.06 g/dl or 75 min,), and their interactions. The dependent variables were measures of subjective response to alcohol (BAES and POMS) and alcohol craving (AUQ). Secondary analyses examined the effects of Severity Factor, Alcohol, and
