and 3 at BrAC = 0.06 g/dl or 75 min,), and their interactions. The dependent variables were measures of subjective response to alcohol (BAES and POMS) and alcohol craving (AUQ). Secondary analyses examined the effects of Severity Factor, Alcohol, and their interaction on measures of subjective response and craving. OPRM1 was retained in the alcohol severity models for outcome variables (i.e., subjective responses) in which genotype was a significant predictor. Alcoholism severity is tested in separate models given thatthe alcohol severity hypothesis is fairly novel and to our knowledge, similar models have not been reported in the literature to date. For those reasons, analyses of the alcoholism severity factor represent the secondary/exploratory aim of the study and were tested in separate models.
