P3 and FT. In a recent study, low target-related P3 and FT in early adolescence were shown to prospectively predict drinking in late adolescence, independent of one another. The study also showed that among alcohol-naïve individuals, low P3 and FT increased the odds of new onset of alcohol behaviors three years later (Harper et al., 2021). Therefore, both low P3 and FT are considered endophenotypes with high predictive utility for examining risk for developing AUD even prior to alcohol initiation. Conversely, evidence shows that greater attention and inhibitory control produce larger P3 amplitudes (Brennan & Baskin-Sommers, 2018). Likewise, higher FT is linked with more efficient cognitive processing involving frontal inhibitory control (McLoughlin et al., 2022).
