AUDADIS family history variables is very good to excellent (Grant et al., 2003; Hasin et al., 1997). The binary parental history variable was coded as “yes” if alcohol problems were reported for either the father or mother, since the frequency of a maternal history alone or of two parents with a history of problems was very low. Prevalence of a parental history of alcohol problems was ~16%; 24% of participants who had experienced childhood adversity also reported a parental history of alcohol problems, compared with 14% of those who had not experienced childhood adversity. Secondary analyses adjusting for parental history of alcohol problems in the relationship between childhood adversity and alcohol phenotypes yielded results that were virtually unchanged. Further, a concern that associations could be confounded by parental alcohol problems is addressed in part by ADH1B-rs1229984 genotype GG not being associated with the adversity group (p=0.90), or with parental history of alcohol problems (p=0.44). The lack of association between genotype GG and parental alcoholism is most likely due to the low rates of alcohol consumption (and related problems) in the parental cohort of older Israelis (Levav et al., 1993). Finally, the interaction results described in this study should be replicated
