The cosplicing network was formed as described elsewhere (Iancu et al. 2015). Twenty-nine genes displayed alternative exon usage (AEU, identified as splicing significance in Table S2), no genes displayed DV in splicing patterns and 1633 genes exhibited DW (FDR < 0.05; Table S2). Only the DW genes were analyzed further. The DW genes were enriched in annotations associated with Golgi vesicle transport, the nuclear pore and Ras GTPase binding (Table S8). Genes in the latter category included a cluster of Rab-, Rap- and syntaxin-binding protein-associated genes. The DW genes were significantly enriched in three cosplicing modules [brown (P < 4 × 10−27), green (P < 1 × 10−21) and yellow (P < 7 × 10−8), Table S8]. The brown module was significantly enriched in annotations associated with GTPase binding, as was the green module. The green module also showed enrichment in neuronal membrane annotations, e.g. neuron part (P < 10−7) and post-synaptic density (P < 9 × 10−7). Genes in the latter category included Gria1, Gria3, Htr2a and Htr5a.
