In addition, the H1 haplotype was associated with greater alcoholism risk (p = 0.032). The H1 × trauma interaction was also significant (p = 0.029) and the parameter estimate was negative (β = −0.30, SE = 0.14, p = .029). As shown in Figure 2, among individuals not exposed to trauma, the H1/H1 diplotype is a risk factor for AD relative to the H2/H2 diplotype; however, with trauma exposure carriers of the H1/H1 diplotype are more resilient to the development of AD relative to H2/H2 carriers.
