Based on the volume conductor theory several current source density (CSD) methods have been proposed to solve for the current sources and sinks from LFP and EAP data (Nicholson and Freeman, 1975; Mitzdorf, 1985; Plenz and Aertsen, 1993; Okada et al., 1994; Pettersen et al., 2010; Łęski et al., 2011). A volume CSD approach for measurements using a 3D MEA has also been done (Riera et al., 2014). These methods approximate the location of the sources prior to solving the CSD and may not be suitable for localizing single neurons. Different methods to localize single neurons depend on the source models used, e.g., monopole source type models such as exponential decay and inverse power law models (Blanche et al., 2005; Chelaru and Jog, 2005; Kubo et al., 2008), dipole models (Blanche et al., 2005; Mechler and Victor, 2012), line source models (Somogyvári et al., 2005, 2012), and simplified line model fitted to the perisomatic area of a full-compartmental neuron model (Delgado Ruz and Schultz, 2014).
