Table 1 provides a summary overview of the seven GWAS. We identified a total of 864 “lead associations”: the sum total of the 124 general-risk-tolerance lead SNPs together with the 740 lead SNPs from the six supplementary GWAS. (These 864 lead associations were obtained by considering each of our seven phenotypes separately and using the standard genome-wide significance P value threshold of 5×10–8. If we instead consider the seven GWAS jointly and use a Bonferroni-corrected P value threshold of 7.1×10−9 (= 5×10−8/7), we obtain 566 lead associations across the seven GWAS.) Since we did not have the data to conduct replication analyses of the lead associations from the supplementary GWAS, we calculated the “maxFDR”16, a theoretical upper bound on the false discovery rate (FDR), for each GWAS. The maxFDR estimates were low across all GWAS (the highest estimate was 1.22×10−3, for automobile speeding propensity), thus providing reassurance about the robustness of the lead associations.
