Chunk #22 — Results — Sedative and Ataxic Effects of Acute Administration — Loss of righting reflex

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Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration.

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After administration of 3.5 g/kg ethanol, KO mice showed increased sedation compared to WT (t(22) = −4.4, p<0.001), as measured by a longer duration of the loss of righting reflex (Fig. 1C).