Chunk #31 — Results — Organoids derived from schizophrenia iPSCs—dispersion of proliferating cells in the cortex and blockade of cortical neuronal development
2b). At 5 weeks, the basal cortical Pan-Neu positive neurons in schizophrenia organoids displayed dense short processes, different from the network of the long processes formed in the cortex of the control organoids (Fig. 2b). Overall, density of the Pan-Neu fibers in schizophrenia appeared reduced. This decrease was verified by measuring the Pan-Neu fluorescence intensity in the basal CZ, as compared to the IZ. In three patients (compared to three control individuals), we found a significant reduction in Pan-Neu fluorescence in the basal CZ and no significant change in the IZ (Fig. 2c, d).
