Gene-based analyses for 21 567 genes (protein-coding genes and miRNAs) resulted in an experiment-wise significant result for two genes, the IQ motif containing K gene (IQCK) and the chromosome 16 open reading frame 88 gene (C16orf88; Pcorr<0.0215; P<1×10−6). Both genes are located in the same chromosomal region (16p12.3) and share their leading SNP, i.e. the SNP with the lowest P-value that is annotated to the gene (rs1544352; P=1.94×10−5). The only other gene that shows a P-value < 1×10−4 is the orofacial cleft candidate1 gene (OFCC1; P=6.29×10−5). A more detailed list of association results for the gene-based analyzes are given in Table 3 and a ‘regional association plot’ for the OFCC1 locus is provided in Figure 2.
