Query of the interactome 34 for high confidence interactors of DLGAP1 and GRIK2 identified 169 interactors of DLGAP1 and 161 interactors for GRIK2 (246 interactors for both of them together). Gene-based analyses revealed that 21 (out of 246) genes showed a nominal significant P-value (one-sided P=0.075). This included 16 genes for DLGAP1 (one-sided P=0.069) and 14 genes for GRIK2 (one-sided P=0.135). It is of note that GRIK2 itself was identified as interactor of DLGAP1 and showed a nominal significant gene-based P-value of 0.03. Among the list of other nominal significant genes are the neuronal differentiation 6 gene (NEUROD6, P=0.010), the synaptic vesicle glycoprotein 2A gene (SV2A, P=0.026), the ionotropic, AMPA 4 glutamate receptor gene (GRIA4, P=0.039), and the solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene (SLC1A2, P=0.035). A full list of these results is given in Supplementary Table S4.
