Chunk #18 — 2. METHODS — 2.3 Statistical Analyses — Common Pathway model

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Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms.

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The common pathway model, shown in Figure 1b, is a submodel of the independent pathway model that posits that the covariance among dependence on different substances is due to a single latent trait. The variation in the latent trait is partitioned into its genetic and environmental sources. Like the independent pathway model, the variance specific to each substance is partitioned into genetic and environmental factors.