Chunk #17 — 2. METHODS — 2.3 Statistical Analyses — Independent Pathway model

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Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms.

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The independent pathway model shown in Figure 1a assumes that single genetic, shared environment, and non-shared environment factors explain the comorbidity among dependence on the three substances. Additionally, the model decomposes the specific variance of each substance into its genetic and environmental sources.