The PTSD case-control GWAS for the EUR sample included 36,301 algorithmically defined probable PTSD cases and 178,107 controls. Considering LD-independent loci (r2 > 0.1), we identified three distinct GWS (P < 5 × 10−8) genomic risk loci (Fig. 1 (top) and Supplementary Table 3a) on Chr11:28707675, rs10767744 (MAF = 0.39, P = 1.75 × 10−10), proximity mapped to METTL15; on Chr7:70219946, rs137999048 (MAF = 0.047, P = 1.03 × 10−8), proximity mapped to AUTS2; and on Chr7:1855531, rs7680 (MAF = 0.14, P = 4.17 × 10−8), proximity mapped to MAD1L1, respectively. Regional Manhattan plots for each region are presented in Supplementary Figure 1a–c.
