Among women, PAC was significantly greater for the AUD group compared to unaffected participants in alpha-gamma cluster W16 (U = 18446, p = 0.023, CLES = 0.569, r = 0.139), and cluster W17 (U = 18808, p = 0.0083, CLES = 0.581, r = 0.161). Like men with AUD, the distribution of PAC estimates from women in the AUD group were significantly shifted towards greater PAC compared to those in the unaffected group in clusters W16 (Fig. 3B, cluster 16: AUD median = 0. 756, unaffected median = 0. 743) and W17 (Fig. 3B, cluster 17: AUD median = 0.7499, unaffected median = 0.7352). Review of comodulogram median matrix results indicated that these significant PAC clusters were appearing in the context of greater PAC strength broadly across the alpha-gamma domain of both men (Fig. 2A) and women (Fig. 3A) with severe AUD compared to their unaffected counterparts.
