Figure 7 shows the adverse events rate ratio comparisons in disulfiram treated patients and controls. Disulfiram was associated with an increased risk of any adverse events compared with controls: adverse events rate ratio = 1.40 (95%CI 1.01–1.94). Adverse events were reported in 73% of the studies. In the combined disulfiram groups reporting adverse events (n = 962), eight participants reported serious adverse events requiring hospitalization. Of those, two were hospitalized less than one day and then immediately resumed their participation [25]. The other six were from one other study, but according to the authors, three of them returned to complete the study [38]. In the combined control groups, six participants reported serious adverse events requiring hospitalization from three studies [38], [39], [42]. In one cocaine study, serious adverse events were not specified for those patients with a co-dependency alcohol and cocaine [14].
