to PFC and to lateral OFC. In previous studies, the dysfunction of lateral OFC found in drug addicts was thought to be implicated in the core characteristics of drug addiction, such as failure to properly inhibit excessive drug consumption and develop aversive/withdrawal reactions to potentially dangerous situations (Goldstein et al., 2005; Goldstein et al., 2001; Volkow et al., 2003). Our observations may suggest that, in drug addicts, there may be abnormally excessive influences of drug and drug cues-induced craving to the behavioral guidance function, while the ability of behavior changing according to cognitive control and the function of evaluating punishment value of reinforcers (such as negative consequences of drug taking) may be impaired. As drug addiction is characterized by the failure to resist one's impulses to obtain and take addictive drugs despite serious negative consequences (Volkow and Li, 2004), our functional connectivity findings may provide a neurobiological explanation for this phenomenon.
