The OFC is a functionally heterogeneous region that involved in complex adaptive behaviors: the medial part of OFC appears to be involved in ongoing monitoring of the reward value of reinforcers, while the lateral part is involved in both evaluating the punishment value of reinforcers and behavioral guidance functions which may lead to a change in current behaviour (Elliott et al., 2009; Kringelbach, 2005; Kringelbach and Rolls, 2004; Murray et al., 2007; O'Doherty et al., 2001; O'Doherty, 2007). In the present study, we respectively analyzed the functional connectivity of these two sub-regions of OFC. We found heroin users exhibited enhanced functional connectivity between medial OFC and NAc and within medial OFC, which may correspond to their stronger salience value of drugs. The lateral OFC of heroin users showed stronger functional connectivity to amygdala and to medial OFC but weaker connectivity to PFC and to lateral OFC. In previous studies, the dysfunction of lateral OFC found in drug addicts was thought to be implicated in the core characteristics of drug addiction, such as failure to properly inhibit excessive drug consumption and
