GO annotation of the CeA DW genes revealed a significant enrichment (FDR < 4 × 10−7) in genes (N = 118) associated with the synaptic component (Supplementary Table S8); genes in this category included Cnr1, Dlg1, Gabra4, Gabrb3, Gabrg3, Gphn, Gria2, Grid2, Grik3, Grin2b, Grm5, Slc1a2&3, Stx1b,2&3, and Syap1. The CeA DW genes were enriched in three modules: blue, magenta, and turquoise (Supplementary Table S8). The blue CeA module is described above. The magenta module did not have a significant enrichment in any GO category. The turquoise module was enriched in the categories macromolecule metabolic process (FDR < 1 × 10−8), ubiquitin–protein transferase activity (FDR < 2 × 10−4) and membrane-bound organelle (FDR < 1 × 10−9). It also should be noted that for six modules, the number of DW genes was significantly less than expected; these modules were significantly conserved in response to selection. For the DW genes in the blue, magenta, and turquoise modules, intramodular connectivity (Low vs. High; 0.26 vs. 0.55) was significantly different (p < 1 × 10−95). Large changes (>0.5 in relative connectivity) were noted
