Genetic correlations between gSEM GWAS summary statistics and the external GWAS are presented in Figure 5. No significant associations were observed with alcohol use frequency in adolescence. Drinks per week (rG=.80, 95% CI [0.06, 1.54]), alcohol use frequency (rG=.89, 95% CI [0.02,1.76]), and educational attainment (rG=.40, 95% CI [0.01, 0.80]) were significantly associated with alcohol use frequency in early adulthood. Drinks per week (rG=.84, 95% CI [0.36, 1.31]), AUDIT-P (rG=.54, 95% CI [0.15, 0.93]), alcohol use frequency (rG=.73, 95% CI [.29, 1.17]), alcohol use quantity (rG=.58, 95% CI [0.18, 0.98]), binge drinking frequency (rG=.83, 95% CI [0.33, 1.32]), and a common factor of externalizing behaviors (rG=.23, 95% CI [0.03, 0.43]) were significantly associated with alcohol use frequency in adulthood. Drinks per week (rG=.88, 95% CI [0.47, 1.28]), AUDIT-P (rG=.50, 95% CI [0.19, 0.82]), alcohol use frequency (rG=.89, 95% CI [0.46, 1.31]), alcohol use quantity (rG=.45, 95% CI [0.14, 0.76]), binge drinking frequency (rG=.79, 95% CI [0.39, 1.19]), cigarettes per day (rG=−.27, 95% CI [−0.51, −0.03]) and educational attainment (rG=.26, 95% CI [0.08, 0.45]) were significantly associated with the alcohol use frequency common factor.
