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Chunk #3 — INTRODUCTION

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Reduced left executive control network functional connectivity is associated with alcohol use disorders.
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and bilateral executive control systems (Chakravarthy et al., 2010, Seeley et al., 2007, Damoiseaux et al., 2006, Greicius et al., 2003, Hampson et al., 2006, Smith et al., 2009, Beckmann et al., 2005, Kiviniemi et al., 2009). As long-term heavy drinking has been shown to have detrimental effects on cognition and executive function (Goldstein et al., 2004, Parsons and Nixon, 1993, Pitel et al., 2007, Sullivan et al., 2000), we were particularly interested in networks involved in these functions, specifically the Right and Left Executive Control (R/L ECN). We hypothesized that ALC subjects would have reduced connectivity strength in the both ECNs and that lower ECN connectivity strength would be correlated with disease severity.