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Chunk #58 — Online Methods — Statistical methods — Functional analyses

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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
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We use IPA (IPA®,QIAGEN Redwood City) to identify biological pathways and transcriptional upstream regulators enriched for genes within the BP loci. The transcriptional upstream regulator analysis aims to identify transcription factors, compounds, drugs, kinases and other molecules, for which the target is one of the BP genes under investigation.