of MPAs. In fact, decreased theta power, presence of MPAs and NSSs along with evidence of neurodevelopmental deviance as exemplified by the differential relationship between FP and whole brain volumetric measures with age could be considered as potential endophenotypes of schizophrenia, while the dimension-specific neurobiological indices should be examined in future studies for their potential utility as endophenotypes for the symptom sub-groups. Many of the above-mentioned neurobiological indices implicate fronto-temporal dysfunction as underlying schizophrenia and its symptom dimensions. The frontal pole, which, through its white fiber connections with the medial and lateral temporal regions and the anterior cingulate serves as a central executive, linking the frontal and temporal regions. The FP therefore, could turn out to be a crucial brain region that might help us unravel the nature of the fronto-temporal dysfunction in schizophrenia. It must be highlighted that the above studies provide only preliminary evidence in support of fronto-temporal dysfunction in schizophrenia. There are a multitude of alternate theories regarding the aetiopathophysiology of schizophrenia; a comprehensive discussion of these theories highlighting their relative merits and demerits is beyond the scope of this selective review. Nevertheless, I feel that our findings provide an interesting framework to carry out future studies
