The studies that we have carried out so far provide encouraging links between the homogeneous symptom dimensions of schizophrenia and neuropsychological, minor physical as well as soft neurological neurodevelopmental markers, EEG, and structural brain imaging parameters. The three symptom dimensions viz., positive, negative, and disorganization were present even in neuroleptic-naïve, recent-onset schizophrenia subjects. Among these, the positive and negative dimensions in particular could be linked to neurobiological correlates. Specifically, the positive dimension was associated with higher EEG alpha1 power along with an increased area of the anterior truncus of the CC, which in turn could be an indirect evidence of temporal dysfunction. The negative dimension was associated with frontal executive dysfunction, increased EEG delta power, decreased alpha2 power as well as decreased intra-hemispheric and inter-hemispheric EEG alpha coherences. Both dimensions were associated with decreased EEG theta power and greater prevalence of MPAs. In fact, decreased theta power, presence of MPAs and NSSs along with evidence of neurodevelopmental deviance as exemplified by the differential relationship between FP and whole brain volumetric measures with age could be considered as potential endophenotypes of
