For both Amerindians and East Asians the exclusion criteria used in these analyses also would result in excluding a relatively large number of subjects for these specific ancestries. For example, 10% non Amerindian exclusion would result in excluding 17% of the Amerindian subjects using 128 In4. While this result is probably partially due to European admixture, there also is some difficulty in fully resolving AMI and EAS ancestry at this level. This issue is less severe when the criteria is set at 15% non-membership but is much more problematic when smaller In4 marker sets are used (Table 3). Nevertheless, investigators can use these criteria to improve analyses by excluding most subjects from disparate ancestry regardless of whether they are the result of miss-self-identification and/or due to mislabeling of samples.
