Based on previous findings, we hypothesized that AUD would lead to increased FC in the insula—ACC of the SN, in the PCC—hippocampus of the DMN, and decreased FC in the DLPFC—parietal cortex of the ECN (18–20). In addition, we expected individuals with AUD to exhibit gray matter reduction in the insula and ACC of the SN, in hippocampus of the DMN, and in the DLPFC of the ECN (7–9). We also expected the degree of structural change and functional dysfunction in the neural areas implicated in these networks to be significantly correlated.
