These data should be considered in light of several limitations. First, the younger cohort was scanned on a 1.5T magnet using a spiral acquisition, while the older cohort was imaged on a 3T system using an EPI acquisition. Although data were collected on disparate field strengths the relative relationships between the regions of interest should be proportionately scaled (70). Also, reported differences in functional connectivity across magnet strengths appear to be more pronounced in non-task related demands (i.e., resting) (71). Importantly, comparisons across field strength and technique suggest comparable signal dropout between 1.5T spiral and 3T EPI acquisitions in regions other than the frontal orbital cortex (72). Second, the demographic makeup of our sample may attenuate FH effects on functional connectivity. Most participants are from relatively affluent areas of San Diego and have highly educated parents. Genetic risk for AUD is less likely to be expressed in such environments (73). Sampling a greater number of participants with increased risks for AUD might increase the likelihood of finding FH effects on neuromaturation. Third, our OA group was not wholly comprised of
