Functional connectivity in the resting-state is an important approach to investigate the intrinsic activity of the human brain. Recent studies of resting-state fOT have emerged as a hot topic and revealed that resting-state brain network is an inherent characteristic of the resting brain [49]. Brain functional connectivity is a complex mechanism especially in the PFC region that includes many complex brain functions, which associated with several neurodegenerative diseases. The gender effects should be necessarily considered for the functional connectivity studies with fOT measurement. Our result suggest that the gender effects of hemispheric asymmetry in spontaneous low-frequency hemodynamic fluctuation may provide useful information to understand the gender difference and may improve the accuracy of the assessment during the resting-state condition in future fOT studies.
