Many of the discoveries described here have been overlooked in the oganoid literature in the past six years or so. Many scientists have contributed to the technological development of systems allowing the culture of organoids from practically any mouse or human organ: It behooves those newcomers who publish under the title of organoids to familiarize themselves with the history and accomplishments of past pioneers, many of whom are no longer with us. This will allow a depth of appreciation that is needed to solve problems in developmental biology, differentiation, mechanisms of the maintenance of tissue-specific function, aging, and cancer. There is of course a lot more to do in this field. Exciting new platforms are currently being developed. The advances in biotechnology areas, such as tissue engineering, biomaterials, and micro- and biofabrication, have set the stage for the development of devices where microfabrication and microfluidic technology are combined to support organoid culture and fluid flow, enabling high-throughput testing, environmental sampling, and biosensing (Skardal et al., 2016). These technologies are currently being explored in a range of tissue types and could
