The primary discovery meta-analysis of all ancestry-stratified GWAS (Ncase = 14,904; Ncontrol = 37,944) was conducted in METAL56. As the different study designs (family vs. case-control) produced effect sizes that were not comparable, results were combined using weighting by effective sample size (Supplementary Information A7, Supplementary Note B3). Separate ancestry-specific discovery meta-analyses of EU (N = 46,568) and AA (N = 6,280) cohorts were also performed. Heterogeneity was evaluated across all cohorts and between study designs (Supplementary Information A8).
