In addition to the discovery meta-analyses, we conducted meta-analyses for two design subsets. First, we performed sample size weighted meta-analysis of the subset of genetically unrelated individuals in EU (N = 38,686) and AA (N = 5,799) cohorts for use in LD score regression (LDSR) analysis. Second, we performed inverse-variance weighted meta-analysis of genetically unrelated individuals in genotyped cohorts to estimate within-ancestry effect sizes for EU (N = 28,757) and AA (N = 5,799). These effect sizes were then used to compare trans-ancestral fine mapping results using inverse-variance weighted fixed effects, random effects57, and Bayesian58 models (Supplementary Information A7). Supplementary Table S2 summarizes all of the meta-analytic models considered in the current analysis.
