As described below, a novel locus on chromosome 3 was genome-wide significant (GWS) in the trans-ancestral discovery meta-analysis. To seek replication, we examined the association between this locus and DSM-IV AD in two independent AA samples: Yale-Penn 2 (911 cases, 599 controls; tested using GEE) and COGA AAfGWAS (880 cases, 1,814 controls; tested using GWAF59). Association with AD status, broadly defined using hospital and death records, was also examined in the FINRISK cohort (1,232 cases, 22,614 controls) using Firth logistic regression60 (Supplementary Information A1.4; Life Sciences Reporting Summary).
