Post-hoc power analysis was performed for odds ratios ranging from 1.05 to 1.30 and across allele frequencies using CaTS61 with the estimated effective sample size. Power analysis identifies the range of SNP effect sizes the current study was likely to detected at genome-wide significance if such effects exist. Additionally, we made specific comparisons to the distribution of effects for schizophrenia47, obesity62 and major depression48 as meaningful benchmarks to understand the magnitude of effect sizes plausible for AD (Supplementary Information A10; Life Sciences Reporting Summary).
