LDSR analysis63 was performed to estimate the heritability explained by common SNPs in meta-analyses of unrelated EU and AA samples, respectively. LDSR was performed using HapMap3 SNPs and LD scores computed from 1000 Genomes reference samples corresponding to each population (Supplementary Information A11). Conversion of h2g estimates from observed to liability scale64 was performed assuming population prevalences of 0.159 and 0.111 for AD in alcohol-exposed EU and AA individuals, respectively3. Gene-level enrichments were also tested with MAGMA15 (Supplementary Information A12).
