Genetic correlation between AD and 45 traits from LD Hub25 and other published studies16–19,65–71 was examined using LDSR with the same unrelated EU meta-analysis (10,206 cases and 28,480 controls) and precomputed European LD scores. LDSR compares GWAS results for pairs of traits to estimate the correlation in the genetic liabilities explained by all common SNPs in the LD reference panel. To avoid increasing the multiple testing burden, redundant or highly-correlated phenotypes were reduced by manually selecting the version of the phenotype with the greatest predicted relevance to AD, largest sample size, or highest heritability (Supplementary Information A13).
