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Chunk #19 — Results — Gene-based analyses

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Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
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For AUD, we identify 23 GWS genes in EAs, 5 in AAs, and 1 in LAs (Supplementary Fig. 14), many of which are GWS loci in the SNP-based analyses for that trait. For AUD, the loci in EAs that are not GWS in the SNP-based analyses are KRTCAP3, TRMT10A, ZNF512, DCLK2, MTTP, and MCC. In AAs, EIF4E, ADH4, and METAP1 are GWS for AUD, while ADGRB2 is the only GWS locus in LAs.