With the smaller sample numbers, the non-EUR GWAS yielded fewer variants associated with PAU than did the EUR GWAS (Supplementary Table 1). The AFR meta-analysis found two independent ADH1B missense variants (rs1229984 and rs2066702) associated with AUD (Fig. 1b and Extended Data Fig. 1b), which have been reported previously10,28. In the LA samples from MVP, only ADH1B*rs1229984 (lead SNP) was identified (Extended Data Fig. 1c). Two independent risk variants, ADH1B*rs1229984 and BRAP*rs3782886, were reported in EAS previously29. In the small SAS meta-analysis, one intergenic variant (rs12677811) was associated with AUD; however, this SNP was present only in the UKB (Extended Data Fig. 1d).
