For the 10th update of the JASPAR database, we expanded the JASPAR CORE collection by 20% (329 added and 72 upgraded profiles). The new profiles were introduced after manual curation, during which we curated 26 629 TF binding motifs obtained as PFMs or discovered from ChIP-seq/-exo or DAP-seq data. We also revised 2500 profiles from JASPAR 2022 to either promote them to the CORE collection, update the associated metadata, or remove them because of validation inconsistencies or poor quality. The insects and nematodes taxonomic groups received significant additions in the CORE collection (90% and 140% increase, respectively). Preparing this anniversary update, we focussed not only on expanding our profile collections but also on revisiting the quality of current motifs, especially renewing annotations for plant TF families and classes according to the Plant-TFClass (36) and searching for validation for profiles in UNVALIDATED collection.
