As seen in Table 2, all five of the high alcohol-consuming rat lines consume greater than 5 g/kg/day of ethanol and depending on the specific voluntary drinking protocol produces BACs that range between 50 and 200 mg% (i.e., BACs attainable in humans with AUDs). Similarly, all five of the alcohol-preferring rat lines display relapse behavior, as indicated by an ADE, upon re-exposure to ethanol access (Table 2). In addition, four of the five high alcohol-drinking rat lines have been shown to find ethanol reinforcing, because they operantly self-administer ethanol, and develop tolerance to ethanol-associated effects. However, only three of the rat lines display motor activation associated with ethanol consumption and only two of the rat lines show overt signs of withdrawal during initial abstinence from ethanol. Neurobehaviorally, findings on anxiety-associated differences between high and low ethanol-consuming rats across line-pairs have been mixed. Differences are often contingent upon the experimental or measurement procedure used. For instance, the ability to detect intra-line-pair differences seen in general activity, and other parameters, differs across three test procedures (i.e., Multiple Concentric Square Field, Open Field
