For the main effect of diagnosis, one component comprising 200 edges connecting 54 regions was significant (p < .001, corrected; Figure 4, top middle). For all edges, functional connectivity was reduced in schizophrenia patients. The most affected regions included bilateral hippocampi, middle temporal, and lateral pre-frontal cortex. Most of these connections linked frontal cortex to posterior regions: 34% were frontotemporal, and 20% were fronto-parietal (Figure 4, bottom middle). Most of the remaining connections were either temporoparietal (18%) or occipitotemporal (10%). Similar findings were obtained across different values of K (Figure S2 in Supplement 1).
