One connected component, comprising seven edges connecting eight regions, demonstrated a significant cue-by-diagnosis interaction (p = .042, corrected; Figure 4, top right). Approximately two thirds of these involved frontal regions: 29% were frontofrontal and 29% were frontoparietal. For each edge, control subjects showed a B cue > A cue task effect on connectivity, whereas patients showed the reverse pattern (Figure S3 in Supplement 1). These findings were not significant for k = .01 or k = .001.