Chunk #26 — RESULTS — Reductions in responding for ethanol after GABAAR α4 subunit knockdown are present when testing occurs at the time of maximal knockdown and require ethanol reinforcement
In contrast, when responding was not reinforced by ethanol at test, there were no significant group differences in active lever responses on day 18 after viral infusion (Fig. 3d; P > 0.05). This lack of effect on unreinforced responding was also apparent in the within-session analysis [Fig. 3e & f; baseline: main effect of time (F(5,70) = 81.26, P < 0.0001); virus treatment (F(1,70) = 0.8, P = 0.38); treatment by time interaction (F(5,70) = 0.11, P = 0.98); day 18: main effect of time (F(5,70) = 25.8, P < 0.0001); virus treatment (F(1,70) = 1.5, P = 0.23); treatment by time interaction (F(5,70) = 1.9, P = 0.1)].
