Chunk #11 — METHODS AND MATERIALS — Estimation of number of risk genes

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De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

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We first used a maximum likelihood estimation (MLE) method to estimate the number of genes contributing risk to OCD, based on vulnerability to de novo damaging variants (41). See Supplemental Methods. Next, we used an alternate method for estimating the number of risk genes, using a statistical method based on the “unseen species” problem (39). See Supplemental Methods for details of these calculations.