infusions of CP-55,940, Δ9-THC, or WIN 55,212-2 were found to disrupt performance in radial arm maze, t-maze delayed alternation, passive avoidance, and place recognition memory tasks (Egashira, et al 2002; Lichtman, et al 1995; Mishima, et al 2001; Suenaga and Ichitani 2008; Suenaga, et al 2008; Wegener, et al 2008) . Moreover, studies have demonstrated that infusions of Δ9-THC into the hippocampus, as compared to other brain regions, impair memory performance in the radial arm maze task (Egashira, et al 2002). Similarly, administration of WIN 55,212-2 into the dorsal hippocampus, but not into the ventral hippocampus, nucleus accumbens, ventral tegmental area, or medial prefrontal cortex, selectively impaired retrieval memory in the radial arm maze without effecting prepulse inhibition (PPI) or locomotor activity (Wegener, et al 2008). In addition, post-training intrahippocampal administration of WIN 55,212-2 disrupted long term spatial memory, but not acquisition or short term memory, in a rat reference memory task in the water maze (Yim, et al 2008). Systemic administration of the CB1 receptor, AM281, blocked the memory disruptive effects of intrahippocampally administered WIN 55,212-2 in the t-maze delayed alternation and place recognition tasks (Suenaga and Ichitani 2008; Suenaga, et al 2008).These findings, taken together, suggest that the
