When we considered the LECN and RECN independently, the 2 RAIs were defined corresponding to composite network associations. Because participants showed significantly more relative head motion in the abstinence vs smoking states (P = .02), head motion was included as a covariate in addition to age, years of smoking, FTND, and IQ. The 3-dimensional rendering maps in Figure 2 illustrate the composition of the RAI in both hemispheres and the change in the RAI between abstinent and smoking states. The RAI decreased significantly in the abstinence compared with the smoking state (left RAI, P = .002; right RAI, P = .04).
