In Cohort II, for both women and men, a similar pattern is found when AD is modeled as a time-varying predictor of reproductive onset. In unadjusted models, onset of AD is associated with delayed reproduction in female twins after age 24, with 38% decreased probability of first childbirth. AD onset is also associated with delayed reproduction in adjusted models, but with reduced effect and no significant age interaction. In adjusted models, with MDD, suicide attempt, panic attack, and CSA also modeled as time-varying predictors, AD is associated with 23% decreased probability of first childbirth among women. For male twins, onset of AD shows no significant association with age at first reproduction in either unadjusted or adjusted models. Subsidiary Analyses
