Chunk #18 — MATERIALS AND METHODS — Statistical model — QuantiSNP: an Objective Bayes Hidden-Markov Model — Posterior measures

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QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

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Aberration events are defined as excursions of the sequence out of the normal states. For each aberration event given by the Viterbi algorithm, which spans a region from SNP i to j with copy number k, we associate with that event a Bayes Factor BF given by, 12