Here we present a genome-wide meta-analysis identifying the first genome-wide significant loci for ADHD using a combined sample of 55,374 individuals from an international collaboration. We also strengthen the case that the clinical diagnosis of ADHD is the extreme expression of one or more heritable quantitative traits, at least as it pertains to common variant genetic risk, by integrating our results with previous GWAS of ADHD-related behavior in the general population.